The Evaluation of New Biomarkers of Inflammation and Angiogenesis in Peripheral Arterial Disease

Peripheral artery disease is a clinical manifestation of atherosclerosis with significant morbid‐ ity and mortality (Sharma Sharma & Aronow, 2012; Resnick et al. 2004; Diehm et al. 2009). Despite well-recognized significance of traditional risk factors in the initiation and progression of the disease, not all causes and mechanisms leading to disease development have been identified so far. Inflammation, angiogenesis, and endothelial activation are important processes contributing to the pathogenesis of peripheral arterial disease which are related in a complex and interdependent manner (Li et al., 2007; Brevetti et al., 2010; Brevetti Get al., 2003; Brevetti et al., 2008; Findley et al., 2008).